The synagogue in Velyki Mosty was founded not long before or after 1900. Today it is in ruins. For a long time the synagogue served as the centre of cultural and community life. During World War II, with the arrival of the Nazi troops in Velyki Mosty, it was right in the territory of the former synagogue that mass executions of peaceful Jewish residents of the urban village were staged, and the Germans burnt many local Jews alive in the building of the synagogue.
After the war it was used as a storage facility for the bones of cattle. In the 1950ies a hurricane destroyed the roof, and since then the building has not been reconstructed.
The synagogue is a brick building. To the north from the synagogue there is a mikvah. The main hall is almost square (16 × 16 m), and almost 8 m high. In the middle the main hall is divided by square arcs into 9 parts. The survived matsevas from the destroyed cemetery are piled in the middle of the temple.